YRMC In Yum A Case Study
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Get Toned at Home: A YRMC Healthy Conversations Presentation
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Drug: Osimertinib Participants will receive osimertinib capsules orally. Drug: Placebo Participants will receive matching placebo orally. Drug: Lazertinib Participants will receive lazertinib tablets orally. Secondary Outcome Measures : Overall Survival OS [ Time Frame: Up to approximately 60 months time from the date of randomization until the date of death due to any cause ] Overall Survival is defined as the time from the date of randomization to the date of participant's death due to any cause. Progression-Free Survival After First Subsequent Therapy PFS2 [ Time Frame: Up to approximately 42 months ] The PFS2 is defined as the time from randomization until the date of second objective disease progression, after initiation of subsequent anticancer therapy, based on investigator assessment after that used for PFS or death, whichever comes first.
Any adverse event occurring at or after the initial administration of study treatment through the day of last dose plus 30 days, or until the start of subsequent anticancer therapy if earlier , is considered to be treatment emergent. Number of Participants with Clinical Laboratory Abnormalities [ Time Frame: Up to approximately 60 months ] Number of participants with clinical laboratory abnormalities serum chemistry, hematology, blood coagulation, and urine samples will be reported. Number of Participants with Vital Signs Abnormalities [ Time Frame: Up to approximately 60 months ] Number of participants with vital signs abnormalities temperature, heart rate, respiratory rate, oxygen saturation, blood pressure will be reported.
Number of Participants with Physical Examination Abnormalities [ Time Frame: Up to approximately 60 months ] Number of participants with physical examination abnormalities will be reported. Serum Concentration of Amivantamab [ Time Frame: Up to approximately 42 months ] Serum samples will be analyzed to determine concentrations of amivantamab. Plasma Concentration of Lazertinib [ Time Frame: Up to approximately 42 months ] Plasma samples will be analyzed to determine concentrations of lazertinib.
Number of Participants with Anti-Amivantamab Antibodies [ Time Frame: Up to approximately 42 months ] Number of participants with antibodies to amivantamab will be reported. Each multi-item scale and individual item will be summarized using count and percent by visit. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.
For general information, Learn About Clinical Studies. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Save this study. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Last Update Posted : September 17, See Contacts and Locations. Study Description. The purpose of this study is to assess the efficacy of the amivantamab and lazertinib combination, compared with osimertinib, in participants with epidermal growth factor receptor EGFR mutation Exon 19 deletions [Exon 19del] or Exon 21 LR substitution positive, locally advanced or metastatic non-small cell lung cancer NSCLC.
Detailed Description:. As a clinical lab, Labcorp offers many different types of tests ranging from routine lab tests and blood work to tests required by employers. It is, however, important to call Labcorp to confirm they offer the test you need and determine if you need a referral from a qualified provider. If you do require a referral for a specific lab test, you may want to find and book a visit at a Yuma urgent care. No Ratings. Call for Visit Is this your business?
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